General Information

  • ID:  hor001616
  • Uniprot ID:  P41486
  • Protein name:  FMRFamide-like neuropeptide 3
  • Gene name:  NA
  • Organism:  Homarus americanus (American lobster)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SDRNFLRF
  • Length:  8(1-8)
  • Propeptide:  SDRNFLRF
  • Signal peptide:  NA
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This peptide can act as a modulator of exoskeletal and cardiac neuromuscular junctions.
  • Mechanism:  Pericardial organs release this peptide with 100 mm potassium in the presence of calcium.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001616_AF2.pdbhor001616_ESM.pdb

Physical Information

Mass: 117920 Formula: C47H71N15O13
Absent amino acids: ACEGHIKMPQTVWY Common amino acids: FR
pI: 10.4 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -92.5 Boman Index: -3772
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 2003.75 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3429714
  • Title:  Purification and Characterization of FMRFamidelike Immunoreactive Substances From the Lobster Nervous System: Isolation and Sequence Analysis of Two Closely Related Peptides